For more than 30 years, our laboratory has sought to elucidate the genetic foundation of mammalian craniofacial development, normal and abnormal. Our working assumption has always been that biologic information is composed of the digital information of the genome and the analog information of the environment outside the genome. Integration of such information results in dynamic quantitative models that are predictive of emergent phenotypes. To this end, we utilize transcriptomics, proteomics, computational biology, and reverse chemical genetics to identify cell-directed therapeutic targets (e.g. small molecule inhibitors). The success of our efforts will be judged by others. We can only hope for some measure of value in the contributions we make to the understanding of the etiology of abnormalities of oral structures, the face, and the brain.